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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our exploration interests include:

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Round the identical time, the group of Paul McEuen, who was then centered for the University of California, Berkeley, showed similar success on ropes of bundled nanotubes. Dependant upon the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified employing scanning tunnelling spectroscopy experiments.

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

We create point-of-treatment diagnostics examination of neglected tropical ailments within useful resource-minimal options, depending on Crspr/Cas9 detecting of pathogen’s DNA in body fluids.

Within the years next these discoveries, my investigate pursuits shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The focus of numerous scientists in the sector also shifted to graphene (exactly where, funnily adequate, the very first graphene ribbons were being referred to as ‘nanotubes which can be Reduce open up alongside their length’) just after the invention of the two-dimensional product in 2004.

All parameters were the identical for every panel In this particular video, except for the initial placement from the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early as a consequence of translocation of the rod through the pore are marked by a grey background.

Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation

The rotors harness Electrical power from a nanoscale h2o and ion flow that is definitely generated by a static chemical or electrochemical likely gradient in the nanopore, which might be established by way of a salt gradient or used voltage, respectively. These artificial nanoengines self-Arrange and work autonomously in physiological circumstances, suggesting solutions to constructing Strength-transducing motors at nanoscale interfaces.

Bulk-area coupling identifies the mechanistic connection concerning Min-protein styles in vivo As well as in vitro

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Nanoscientist Cees Dekker is an amiable and flamboyant gentleman who seems Significantly young as opposed to sixty two a long time he basically is – fashionable Eyeglasses, psychedelic shirt, partaking smile – but not just one to squander time. He will take his time, but not more than essential.

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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap ceesdekker.net en de discussie rond smart design in 2005. (nl)